Alexis Sanchez is likely to make himself available for first-team action from a minor injury spell, and will be expected to add pace and attacking power to Arsenal.
After a last-gasp draw against West Ham, Manchester United will be aiming to return their winning ways when they take on Burnley at Old Trafford.
Marseille’s patchy form has saw them lose their grip on the top of the Ligue 1 leaderboard, and a win against the Stade Reims will be the perfect tonic to get their season back on track.
Buoyed by a run of good results, West Ham is brimming with confidence ahead of their 5th round FA Cup tie against West Brom and aim to steal an away win to progress in the competition.
Liverpool is desperate to win the FA Cup since they last won it in 2006, but Crystal Palace is a much tougher proposition since the arrival of Alan Pardew, and also have ambitions of eliminating a tournament favourite.
FA Cup giant-killers Middlesbrough will travel to Emirates stadium to face Arsenal as the Championship side hopes to repeat their impressive performance that beat Man City in the previous round.